How does mibefradil affect the heart

These patients had other medical conditions and other medications such as doxazosin , which may have contributed to the hypotension they experienced. However, the timing of hypotension soon after ingesting the CCB within a day of taking mibefradil suggests that this combination should be avoided.

The long half-life of mibefradil hours 8 may require a prolonged washout period before considering therapy with another CCB. Furthermore, in patients who do not achieve adequate blood pressure control with mibefradil, which blocks both T-type and L-type calcium channels, CCBs that block only L-type calcium channels would be unlikely to improve blood pressure control.

Angiotensin-converting enzyme inhibitors, angiotensin II antagonists, and diuretics do not require special precautions. High-dose glucagon mg intravenously increases intracellular cyclic adenosine monophosphate and produces positive inotropic, dromotropic, and chronotropic effects. Vasopressors, inotropes such as amrinone 14 , and temporary pacing may be necessary.

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue. Mibefradil: a new calcium channel blocker. Med Lett. Google Scholar. Neergaard L. Heart drug pulled from market. Associated Press. June 8, Voluntary market withdrawal, Posicor [Dear Doctor letter]. Safety of mibefradil, a new once-a-day, selective T-type calcium channel antagonist.

Am J Cardiol. Mibefradil, a novel calcium channel antagonist, in elderly patients with hypertension: favorable hemodynamics and pharmacokinetics. Am Heart J. Additional antianginal and anti-ischemic efficacy of mibefradil in patients pretreated with a beta-blocker for chronic stable angina pectoris.

Dear Doctor letter. Posicor [package insert]. Important information on drug interaction and therapy substitution for Posicor [Dear Doctor letter]. Doyon S, Roberts JR. The use of glucagon in a case of calcium channel blocker overdose. Ann Emerg Med. Amelioration of nifedipine poisoning associated with glucagon therapy. Glucagon and phenol toxicity. Massive verapamil ingestion: a report of two cases and a review of the literature. Am J Emerg Med.

Use of amrinone and glucagon in a case of calcium channel blocker overdose. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume 3. Article Contents Abstract. Mibefradil — a drug which may enhance the propensity for the development of abnormal QT prolongation.

Meinertz T. Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany. Oxford Academic. Google Scholar. Cite Cite T. Select Format Select format. When given orally once daily to patients with hypertension mibefradil produces a dose-related decrease in blood pressure which is sustained for 24 hours and improves exercise performance in patients with stable angina pectoris.

In patients with generally mild to moderate hypertension oral mibefradil was superior to nifedipine SR and diltiazem CD, tended to be more effective than nifedipine GITS and had similar efficacy to amlodipine.

Mibefradil 50 to mg once daily also has antianginal and anti-ischaemic effects. The drug improves the duration of symptom-limited exercise and the time to onset of ischaemia, and reduces the frequency of anginal attacks and consumption of nitroglycerin.